The glutamine commute

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The glutamine commute

The transfer of glutamine between cells contributes to signaling as well as to metabolism. The recent identification and characterization of the system N and A family of transporters has begun to suggest mechanisms for the directional transfer of glutamine, and should provide ways to test its physiological significance in diverse processes from nitrogen to neurotransmitter release.

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In multicellular organisms, the diverse function of specialized tissues requires mechanisms to coordinate their activity. This generally involves signaling between cells. In many cases, a soluble signal released by one cell activates the receptor in a second cell. In other cases, the signal involves contact with extracellular matrix rather than a soluble mediator or direct contact between cells...

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The glutamine commute : take the N line and transfer to the A

In multicellular organisms, the diverse function of specialized tissues requires mechanisms to coordinate their activity. This generally involves signaling between cells. In many cases, a soluble signal released by one cell activates the receptor in a second cell. In other cases, the signal involves contact with extracellular matrix rather than a soluble mediator or direct contact between cells...

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ژورنال

عنوان ژورنال: Journal of Cell Biology

سال: 2002

ISSN: 1540-8140,0021-9525

DOI: 10.1083/jcb.200201070